Thursday, September 23, 2010

What is mutagenesis effects and teratogenic effects of Caffeine and Paracetamol?

T_TWhat is mutagenesis effects and teratogenic effects of Caffeine and Paracetamol?
I looked it up on the magic internet. It say that caffeine has anti-mutagenic effects on cell:
http://mutage.oxfordjournals.org/cgi/rep...
But then this one say it has both mutagenesis effects and teratogenic effects:
http://science.jrank.org/pages/1115/caff...
This website say: "In the MTA, even with 200 micrograms/ml caffeine, the toxicological parameter obtained by proliferation and differentiation assays of the midbrain and member bud cells be almost the same as contained by the control. In conclusion, caffeine induced various morphological anomalies, but did not affect proliferation or differentiation of cell in these experimental systems."
from
http://grande.nal.usda.gov/ibids/index.p...
As for paracetamol, this website say that although paracetamol can cross the placenta, no tetatogenic effects have be observed in mice, up to 250mg/kg:
http://www.sanofi-aventis.com.au/product...
Apparently, it can hold mutagenetic effects, however. One website says: "Paracetamol inhibits replicative DNA synthesis and induces sister chromatid exchange and chromosomal aberration by inhibition of ribonucleotide reductase", this is from
http://mutage.oxfordjournals.org/cgi/con...
I hope this helps
Ashley
Walk into a pharmacy, ask for the prescribing information, and check the gram tryout for each of them?

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